Role Of Lymphatic Polychemotherapy And Ehf Therapy In Treatment Of Colorectal Cancer Complicated By Carcinomatosis Of Abdominal Cavity

E AKBAROV, S Navruzov, S Abdujapparov, H Islamov


Aim: to improve treatment results of colorectal cancer, complicated carcinomatosis of abdominal cavity, by associated using of endolymphatic chemotherapy (ELCT) and local extremely high frequency (EHF) therapy.

Materials and methods: I-group – 21 people (33.3%) performed colostomy, then neoadjuvant systemic chemotherapy by the scheme FOLFOX-4. It was held two cycles, after two cycles their were received cytoreductive surgery;

II group – 26 people (41,3%) received cytoreductive operations with early postoperative intra-abdominal chemotherapy by oxaliplatin (200 mg/m(2) at day 1 and 5-FU 650 mg/m(2) from days 1 to 4.

III group – 16 people (25,4%) also performed colostomy, then used 2 courses of ELCT with local EHF therapy and all patients were received cytoreductive operations. ELCT was carried out injecting oxaliplatin-100 mg/m(2) a day during 12 hours and then 5 – FU in doze of 600 mg/m2 a day during 72 hours by the instrumentality of the dozer and LV-200 mg/m(2) (2-h intravenous infusion). During ELCT patients received local EHF therapy in abdominal cavity for an hour.

Results: After chemotherapy the partial regress of tumor observed in 1st group in 4,8 % and in 3rd –37,5 %, stabilization of process noted in 28,6 and 50% cases, progressing –66,7 and 12,5% cases correspondingly to groups. Histomorphologic study of malignant foci after ELCT+EHF therapy showed reduction of specific area of parenchyma cancer cell from 57 till 39% simultaneous growth of stroma from 40 till 58% and in necrosis area – from 1,8 till 2,5%. Mitotic activity of tumor cells in the 1st group decreased (average in 22 un.), but in 3rd group it decreased until 11 units. 

Analysis of life span showed that in 1st group of patients 2-year survival rate was 66,7%. In 2nd group of patients 2-year survival rate was 42,3%. 

Сonclusion: ELCH+EHF-therapy has high clinic efficacy and promotes to decrease terms of progression of tumor process, increases life span from 0 till 24% and quality of life of the patients. ELCH+EHF-therapy brings to reduction of specific area of parenchyma in cancer cells from 57 till 39% with simultaneous growth of stroma area from 40 till 58% and necrosis area – from 1,8 till 2,5%. ELCT+EHF-therapy lowers mitotic activity of tumor cells, activates apoptosis, hemodynamic and metabolic rates.


Colorectal Cancer, Complex Therapy, Endolymphatic Chemotherapy, Extremely High Frequency Therapy

Full Text:



Reports of ROSC, Ministry of Public Health of Republic Uzbekistan. Decease statistics and death rate from malignant neoplasms in 2008, Tashkent. Medicine 2009; p.52

Chissov VI, Starunskiy VV, Kovalev BN. Organizational context of early detection in malignant neoplasms. Russian oncological journal 2002; (2): p.43–45

Prorokov VV, Malihov AG, Knish VI. Modern principles of diagnostics and screening of rectal cancer. Practical oncology selected lectures S.Pitersburg 2004; p.162–167

Crane CH, Skibber JM, Birnbaum EH. The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2003; 57(1): p.84-89

Knish VI, Cherkes VL, Ananyev VS. Methods to improve the results of treatment of colorectal cancer. Russian Oncol Jour 2001; (5): p.25-27

Kurpeshev OK, Tsib AF, Mardinskiy YS. Development mechanisms and overcoming methods of tumor chemoresistance. Rus Onc J 2003, (2): p.50-53

Nevolskih AA. Influence of local hyperthermia on late result combination therapy locally advanced rectal cancer. Med Redio Scien Center of Rus AMS cand. Med. Scien, code of speciality 14.00.14 М 2001; p.19

Tsarkov PV, Vorobyov GI, Odaryuk TS. Place and role in balled aorta-iliac pelvic lymphadenectomy in trearment cancer of low ampullar section of rectum. Practical oncology: Selected lectures 2004; p.168–180

Zolotuhin SE, Dones VL, Melnik ND. Rectal cancer with generalization resulting process of palliative exsection. Thesis II congress of oncologists of CIS countries, Kiev. Oncology 2000; (22): p. 733.

Tamrazov RI. Preoperational thermoradiotherapy in combination therapy of patients with rectal cancer. Russian Oncol Scien Cen named after Blokhin NN, AMS cand. Med. Scien, code of speciality 14.00.14 author's abstract М. 2001; p. 25

Kayrak OS, Lisovskaya N, Kuzmenko Y. Modifier usage in conduction of endolymphatic therapy of patient malignant tumor. Thesis II congress of oncologists of CIS countries, Kiev. Oncology 2000; (22) p. 324

Kolesnik YA. Effect of endolymphatic polychemotherapy and local SHF-hyperthermia in multymodality therapy of rectal cancer. Clinical Surgery 1998; (8): p.32-33

Kunisaki C, Shimada H, Nomura M et al. Does continuous hyperthermic peritoneal perfusion have any prophylactic or therapeutic efficacy on peritoneal dissemination of gastric cancer? 4th International gastric cancer congress, NY, 2001; p.31

Nepomnyashiy YM, Moisenko TI. To morphologic explanation of neoadjuvant chemotherapy of malignant tumor in habitat organism in various modification. Higher education establishments. Natural sciences 2004; (1): p.92-97

Bedrosian I, Rodriguez-Bigas MA, Feig B. Predicting the node-negative mesorectum after preoperative chemoradiation for locally advanced rectal carcinoma. J Gastrointest Surg 2004; 8(1): p.56-63

Chushkin NA, Tupikina GN, Zaharov SN, Salo LY. The immediate result of thermoradiotherapy inoperable rectal cancer in patient aged and senility. Materials of Habrov Land Gerontol Confer Khabarovsk 2000; p.201-202

Cutler SJ, Ederer F. Maximum utilization of the table method in analyzing survival. J Chron Dis 1958; (8): p.699-712

Vashakmadze LA, Trahtenberg AX, Sidorov DV et al. Results of cytoreductive operations in metastatic colorectal cancer. IV congress of oncologists and radiologist of CIS. Baku. 2006; p.150

Yonemura Y. A new treatment strategy for peritoneal dissemination peritonectomy intraoperative chemohyperthermia, and EPIC. 4th International gastric cancer congress. NY 2001; p.335

Katayama K, Kimura T, Iida A. et al.. Chemo hyperthermic peritoneal perfusion (CHPP) to treat peritoneal dissemination of gastric cancer 4th International gastric cancer congress. NY 2001; p.436

Nomura E, Niki M, Fujii K et al. Efficacy of intraperitoneal and intravenous chemotherapy and upper abdominal evisceration for advanced gastric cancer. 4th International gastric cancer congress. NY 2001; p.438

Akbarov ET. Results improving of cancer treatment of rectum by using long time endolymphatic and regional lymphatic polychemotherapy. In press. Tashkent 2005; p.24

Ruo L, Paty PB, Minsky BD. Results after rectal cancer resection with in-continuity partial vaginectomy and total mesorectal excision. Ann Surg Oncol 2003; 10(6): p.664-668

Abelivich AI, Ovchinikov VA. New type of lymphodissection in rectal cancer with metastasis in groin glands. Voprosi Oncologii 2003; 49(6): p.766-768

Lehnert T, Golling M, Buchholz J. Locally recurrent rectal carcinoma. Chirurg 2004; 75(1): p.38-44

Levin YM. Endoecological medicine. Medical bulletin 2002; (5): p. 8



  • There are currently no refbacks.

Print ISSN 1804-5804, Online ISSN 1804-9702

(c) 2018 CBU,o.p.s.