The Study Drug Pathomorphism And Immunohistochemical Parameters Of Tumor In Endoarterial Of Regional Long-Term Chemotherapy In Treatment Of Cervical Cancer

V Navruzova, N Yuldasheva

Abstract


Background: To improve the results of radiotherapy for cervical cancer used local and systemic radio-modification drugs.

Materials and methods: 1984 patients with locally advanced cervical cancer (2b - 3a stage), which at one stage of complex treatment by a course indo-arterial of regional long-term poly-chemotherapy (EARDPHT) mode: methotrexate - 50 mg/m2, the first 12 hours, fluorouracil 1000 mg/m2, over the next 12 hours and cisplatin - 100 mg/m2, for 48 hours, 2 stage - surgical treatment in the volume expanding hysterectomy 3 type (modification of Wertheim - Meigs).

Results: The results of treatment of locally cervical cancer using VADRPHT, depending on the unilateral and bilateral tumor invasion in parametrial tissue showed that under unilateral lesion of parametrium results of treatment were higher than for the bilateral involvement of parametrium. Medical pathomorphosis in tumors of different severity was observed in 86.9% of patients, metastasis to regional lymph nodes were detected in 36% of operated patients, and also studied the degree of therapeutic pathomorphosis in lymph nodes. There was revealed that the complete regression of tumors, 5 - year survival rate is 98%, whereas in tumor regression of more than 50% of the original volume – 78.5%, with stabilization of tumor - no more than 58.4%.

Conclusion:  The study of molecular-biological parameters of the tumor cells show the effectiveness of conducted neo-advent indo-arterial chemotherapy and play an important role in further treatment and prediction of disease.


Keywords


Cervical Cancer, Endoarterial, Chemotherapy

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References


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DOI: http://dx.doi.org/10.12955/emhpj.v1i0.331

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