Assessment Of The Level Of Apoptosis Markers In Women With Non-Developing Pregnancies, Depending On The Origin

Dilnoza Saidjalilova


Based on survey of 257 women with non-developing pregnancies of various geneses, it was shown that the level of apoptosis marker P53 in the decidual tissue is increased, and anti-apoptotic protein Bcl-2 simultaneously is reduced, compared with similar data of women with physiological pregnancies. The morphological and histochemical investigation of apoptotic changes during NDP, by means of Bcl-2 and P53, must consider the main marker in early manifestations of the dynamics of the pathological processes.


Non-Developing Pregnancy, Factors Of Apoptosis

Full Text:



Belushkin, N.N., Severin, S.E., 2001. “Molecular basis of pathology of apoptosis”, [Arhiv Patologii], in Russian, No.1, pp.51-60.

Bushtyryova, I.O., Mikashinovich, Z.I., Shestopalov, A.V., Borisenko, O.V., 2007. “The role of apoptosis in placental development”, [Zhurnal ROAG], in Russian, No.7, pp.49-53.

Chumakov, P.M., 2000. “Function of gen p53: choice between the life and death”, Biochem., Vol.65, No.1, pp.34-47.

Dimmeler, S., Zeiher, A.M., 2000. “Endothelial cell apoptosis in angiogenesis and vessel regression”, Circ. Res., Vol.87, pp.434-439.

Gorbachyova, Y.V., Voloshchuk, I.N., Paltsev, M.A., 2007. “Apoptosis in the trophoblast cells in normally developing pregnancy”, [Molekulyarnaya Meditsina], in Russian, No.2, pp.3-8.

Huppertz, B., Herrler, A., 2005. “Regulation of proliferation and apoptosis during development of the preimplantation embryo and the placenta”, Birth Defects Res. Embryo Today, Vol.75, No.4, pp.249-261.

Lomunova, M.A., Talayev, V.Y., 2007. “Trophoblast cells of human placenta: the ways of their maturation and interaction with the immune system”, [Immunologiya], in Russian, No.1, pp.50-58.

Milovanov, A.P., Boltovskaya, M.N., Fokina, T.V., 2008. “Non-developing pregnancy: histological and immunohistochemical markers of endocrine disruption in endometrial scrapings”, [Arhiv Patologii], in Russian, No.6, pp.22-25.

Milovanov, A.P., Fokina, T.V., Starosvetskaya, N.A., 2007. “Decidualization of the endometrium as a factor regulating cytotrophoblastic invasion during the first trimester of pregnancy”, [Arhiv Patologii], in Russian, No.5, pp.31-34.

Milovanov, A.P., Kirichenko, A.K., 2001. “Molecular mechanisms of regulation of cytotrophoblast invasion in uteroplacental region”, [Arhiv Patologii], in Russian, No.5, pp.63.

Sagatov, D.R., Rasulova, H.A., Madjidova, Y.N., 2010. “Morphological insight into new opportunities using Bcl-2 and P53 in studies of neurotrophicity, neuroprotection and neuroplasticity in brain ischemia”, International Journal of Applied and Fundamental Research, No.4, pp.31-38.

Toki, T., Horluchi, A., Ichikava, N. et al., 1999. “Inverse relationship between apoptosis and Bcl-2 expression in syncytotrophoblast and fibrin-tipe fibrinoid in early gestation”, Mol. Hum. Reprod., Vol.5, No.3, pp.246-251.

Zolotukhin, T.V., 2003. “Clinical and pathogenetic aspects of non-developing pregnancy”, [Rossiyskiy Vestnik akushera-ginekologa], in Russian, Vol.3, No.2, pp.40-44.



  • There are currently no refbacks.

Print ISSN 1804-5804, Online ISSN 1804-9702

(c) 2018 CBU,o.p.s.