Potential Chemopreventive Effect Of “Procont”On Mirna Expression In CBA/CA Mice

Mónika Szirmai, Krisztina Juhász, András Bertha, Katalin Gombos, Péter Révész, István Ember


Background: There is emerging molecular evidence concerning themodification of miR expression pattern after the treatment with chemopreventive agents. We investigated whether a potential chemopreventive agent called “Procont” deriving from a biological systemhas a positive effect on the DMBA induced dysregulation of let-7a, miR-21 and miR-146amiRNAs.Materials and Methods: CBA/CA H2k inbred micewere fed by Procont for 7 days before the intraperitonealinjection of DMBA. After one weekof the beginning of Procont diet weanalized the let7a, miR-21, miR-146agene expression in vital organs of mice. Results:The Procont feeding significantly decreased all of the investigated miRNA expression compared with either the mice on a normal diet in the control group or mice were exposed to DMBA alone.Conclusion:The results indicate that“Procont” diet has a potential chemopreventiveeffect in mice exposed to DMBA.


Procont,Mirna expression,Chemoprevention

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DOI: http://dx.doi.org/10.12955/emhpj.v3i0.350


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