Micronized progesterone as a neuroprotector in pregnant women with post-trauma brain syndrome

Irina Vasilivna Tsyganenko, Vasil Vasilyovich Simrok, Katerina Sergiivna Ruban


The present article is concerned with the study of glial fibrillary acidic protein (GFAP) level in the blood serum of pregnant women  with post–trauma brain injury syndrome (post-TBI syndrome) as the marker of  hematoencephalic barrier status and predictor of obstetric and perinatal complications development.


pregnancy, post–trauma brain syndrome, hematoencephalic barrier, glial fibril-lar acidic protein.

Full Text:



Algattas, H., Huang, J. (2014, January).Traumatic Brain Injury Pathophysiology and Treatments: Early, Intermediate, and Late Phases Post-Injury [Article]. Int J Mol Sci. doi: 10.3390/ijms15010309. http://www.mdpi.com/1422-0067/15/1/309

Cipolla, M., Sweet, J., Chan, S. (2011, February). Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia [Article]. J Appl Physiol (1985); 110(2): 329–339. doi: 10.1152/japplphysiol.01159.2010 http://jap.physiology.org/content/110/2/329

Coelho, C. (2007, May). Management of discourse deficits following traumatic brain injury: progress, caveats, and needs [Article]. Semin Speech Lang.;28(2):122-35.

Daugaard, M., Nielsen, L. (2013, December). Specialised early rehabilitation of brain injury performed in an intensive care setting [Article]. Ugeskr Laeger. 9;175(50):3101-3104.

Deutsch, E., Espinoza, T., Atif , F., Woodall, E., Kaylor, J., Wright, D. (2013, September). Progesterone's role in neuroprotection, a review of the evidence. J Mol Endocrinol. 10;49(3):R125-34. Gao, X., Chen, J. (2011, March). Mild Traumatic Brain Injury Results in Extensive Neuronal Degeneration in the Cerebral Cortex [Article] . J. Neuropathol. Exp. Neurol.; 70(3): 183–191.

Giatti, S., Boraso, M., Melcangi, R., Viviani, B. (2012, October). Neuroactive steroids, their metabolites, and neuroinflammation [Article]. J Mol Endocrinol. 10;49(3):R125-34. doi: 10.1530/JME-12-0127. http://jme.endocrinology-journals.org/content/49/3/R125

Gonzalez-Rey, E., Ganea, D., Delgado, M. (2010, August). Neuropeptides: Keeping The Balance Between Pathogen Immunity and Immune Tolerance. Curr Opin Pharmacol [Article]. Curr Opin Pharmacol.; 10(4): 473–481. doi: 10.1016/j.coph.2010.03.003 http://www.sciencedirect.com/science/article/pii/S1471489210000342

Kuvacheva, N., Salmina, A., Komleva, Y., Malinovskaya, N., Morgun, A., Pozhilenkova, E., Zamai, G., Yauzina, N., Petrova, M. (2013). Permeability of the hematoencephalic barrier in normalcy, brain development pathology and neurodegeneration [Article]. Zh. Nevrol. Psikhiatr. Im S. S. Korsakova.;113(4):80-5

Liddelow, S. (2011). Fluids and barriers of the CNS: a historical viewpoint [Article].2011;8:2.doi:10.1186/2045-8118-8-2 http://www.fluidsbarrierscns.com/content/8/1/2

Melcangi, R., Panzica, G., Garcia-Segura, L. (2011, September). Neuroactive steroids: focus on human brain [Article]. Neuroscience. 15;191:1-5. Paul, E., Rosenberg, M., Keyser, D. et al. (2013). Patient Characterization Protocols for Psychophysiological Studies of Traumatic Brain Injury and Post-TBI Psychiatric Disorders [Article]. Front Neurol. 2013; 4: 91. doi: 10.3389/fneur.2013.00091 http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00091/full

Theadom, А., Starkey, N., Dowell, T., Hume, P., Kahan, M., McPherson, K., Feigin, V., BIONIC Research Group (2014, February). Sports-related brain injury in the general population: An epidemiological study [Article]. J Sci Med Sport. 9. pii: S1440-2440(14)00029-2. doi: 10.1016/j.jsams.2014.02.001.

Wang, D., Bordey, A. (2008, December).The Astrocyte Odyssey. Prog Neurobiol; 86(4):342–367.doi:10.1016/j.pneurobio.2008.09.015 http://www.sciencedirect.com/science/article/pii/S030100820800110X

Yang, Y., Higashimori, H., Morel, L. (2013, August). Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders (Review). Journal of Neurodevelopmental Disorders. doi:10.1186/1866-1955-5-22 http://www.jneurodevdisorders.com/content/5/1/22

DOI: http://dx.doi.org/10.12955/emhpj.v7i1.427


  • There are currently no refbacks.

Print ISSN 1804-5804, Online ISSN 1804-9702

(c) 2018 CBU,o.p.s.