Irina Nakashidze, Nanuli Kotrikadze, Anzor Diasamidze, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani


The significance of ABO blood system groups antigens in development of some malignant tumors is already established. The alteration of  hormonal homeostasis must also be taken into account. Hence the aim  of   the investigation was to study ABO  and Rh blood system antigens and hormonal status among  reproductive age  women with benign and malignant breast   tumors. 

Methods: The determination of  hormones was made by the enzymatic analysis method (ELAIZA), provided by proper ELAIZA kits. For the study of ABO and Rh-Hr system antigens, internationally recognized immunoserology methods were used.

Results: High index of  the breast gland tumors  were  revealed  in  patients with A(II) phenotypic group,  according to the  ABO  system.  The frequency distribution of O(I) phenotypic group was low  among women with breast tumors. Among  D, C, E, c and e antigens of  the Rh system, the frequency of D and E antigens were increased in benign and malignant breast tumors patients. The study of hormonal balance revealed thyroid gland hypofunction and increased level of estradiol on the background of  increased testosterone and decreased progesterone levels. Such hormonal imbalance and  excess  production of estradiol creates conditions for malignant tumor formation in reproductive age women.

Conclusion: The highest frequency of breast cancer in reproductive age was revealed in A(II) group patients. The wide spectrum of hormonal disorders were revealed in breast tumor patients of the reproductive age, which was especially clear in cases of malignant tumor.


breast tumors, blood group antigens, Rh system, hormones.

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