Halidjan Kamilov, Munirahon Kasimova, Gavkhar Khamraeva


Early diagnosis of optic neuritis (ON) is essential to prevent or limit the structural damage and permanent loss of visual function. The aim of this study was to estimate prognostic importance of the neuron-specific enolase (NSE) in blood serum and lachrymal fluid in optic neuritis. The clinical-diagnostic examination was performed on patients with optic neuritis, including optical coherence tomography (OCT) and Visually Evoked Potentials (VEP), MR – tractography, as well as analysis of NSE content in blood serum and in lachrymal fluid.

Decreased level of NSE in lachrymal fluid in patients with acute stage of optic neuritis and increased level of NSE in patients with optic neuritis at the stage of transition into atrophy of optic nerve disc were detected. Comparative analysis demonstrated relatively high level of NSE in lachrymal fluid at transitional stage to atrophy as compared to acute phase.


Optic neuritis, Lachrymal fluid, Neuron-specific enolase.

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Audrey, C. Ko, Hernandez, J., Brinton, J. P., Faidley, E. A., Mugge1, S.A., & Mets, M.B. (2010). Anti-gamma-enolase autoimmune retinopathy presenting in early childhood. Archives of Ophthalmology, 128(12), 1590–1595.

Berger, R. P., Pierce, M. C., Wisniewski, S. R., Adelson, P. D., & Clark, R. S. (2002). Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics, 109, E31.

Brambilla, R., Dvoriantchikova, G., Barakat, D., Ivanov, D., Bethea, J. R., & Shestopalov, V.I. (2012). Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis. Journal of Neuroinflammation, 9, 213. doi: 10.1186/1742-2094-9-213.

Brjevskiy, S., & Somov, E. (1995). The lachrymal fluid the biological material for diagnostic investigations. The Actual Problems of Children Ophthalmology, 28-31.

Chekhonin, V. P., Gurina, I. A., & Rabukhin, I. A. (2000). Immuno-enzymatic analysis of the neuron-specific enolase on the basis of monoclonal antibodies in the assessment of permeability of the blood-brain barrier in the neuro-psychic diseases. Journal of Psychiatry, 4, 15-19.

Chekhonin, V. P., Lebedev, S. V., & Rabukhin, I. A. (2004). Selective accumulation of the monoclonal antibodies to the neuron-specific enolase in the cerebral tissue in the rats with occlusion of the middle cerebral artery. Bulletin of Experimental Biology and Medicine, 138(10), 388-392.

Gelderblom, M. D., Tristan, S., Benjamin, L., & Peter, B. (2013). Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis. Neurobiology of Disease, 59, 177-182.

Maruyama, I., Ohguro, H., & Ikeda, Y. (2010). Retinal Ganglion Cells Recognized by Serum Autoantibody against g-Enolase Found in Glaucoma Patients. Investigative Ophthalmology & Visual Science, 41, 1657-1665.

Pleines, U. E., Morganti-Kossmann, M. S., Rancan, M., Joller, H., Trentz, O., & Kossmann, T. (2001). S-100b reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. Journal of Neurotrauma, 18, 491-498.

Robert, J. B., Ranji, S., & Elias, R. M. (2004). CNS MR and CT findings associated with a clinical presentation of herpetic acute retinal necrosis and herpetic retrobulbar optic neuritis: five HIV-infected and one non-infected patients. American Journal of Neuroradiology, 25, 1722–1729.

DOI: http://dx.doi.org/10.12955/emhpj.v8i1.541


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