SPECIFIC MARKER OF NEURODEGENERATION IN OPTIC NEURITIS

Halidjan Kamilov, Munirahon Kasimova, Gavkhar Khamraeva

Abstract


Early diagnosis of optic neuritis (ON) is essential to prevent or limit the structural damage and permanent loss of visual function. The aim of this study was to estimate prognostic importance of the neuron-specific enolase (NSE) in blood serum and lachrymal fluid in optic neuritis. The clinical-diagnostic examination was performed on patients with optic neuritis, including optical coherence tomography (OCT) and Visually Evoked Potentials (VEP), MR – tractography, as well as analysis of NSE content in blood serum and in lachrymal fluid.

Decreased level of NSE in lachrymal fluid in patients with acute stage of optic neuritis and increased level of NSE in patients with optic neuritis at the stage of transition into atrophy of optic nerve disc were detected. Comparative analysis demonstrated relatively high level of NSE in lachrymal fluid at transitional stage to atrophy as compared to acute phase.


Keywords


Optic neuritis, Lachrymal fluid, Neuron-specific enolase.

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References


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DOI: http://dx.doi.org/10.12955/emhpj.v8i1.541

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